Graduating Class 2019

Sarah Baker

On June 13, 2019, The Rockefeller University will add thirty new alumni to its community, each with a freshly obtained Ph.D. The road to a Ph.D. is not an easy one and requires a combination of hard work, resilience, creativity, motivation, and probably some luck. Some of the graduating class have moved on to new jobs or postdocs elsewhere, whereas others are continuing their work at Rockefeller. This month, the Natural Selections editorial board honors them for their determination and accomplishments. Congrats to our new doctors!

Intimately tied to my time at Rockefeller are my greatest accomplishments, my deepest disappointments, and my fondest friendships—it’s been a ride I feel fortunate to have taken. – Annie Handler

 

RuPaul’s Drag Race All Stars, Season 2, Episode 1, 52:10 – Robert Heler

 

I knew I would get to indulge in creative and exciting science during my time here, but I’m equally grateful for the time I had to enjoy so much of what NYC has to offer from brunch to Broadway and new best friends. – Melissa Jarmel

 

Rockefeller is the best! – Kouki Touhara

 

I didn’t realize how strong people’s feelings could be about free cookies. –Anonymous Graduate

 

Gender Harassment in Science: Instances of Everyday Harm

Emma Garst

*Identifying details have been changed to protect privacy.

When I met her, Laura* was the sort of postdoc who exuded professorial confidence. She was charismatic, a good writer and speaker, and an excellent experimentalist. Our professor sang her praises. Why shouldn’t he? She was talented and motivated.

Some lab members started joking that our professor was “clearly in love with her.” The joke spread; it was an easy way to release tension in a very competitive work environment.  I thought Laura was laughing along with everyone else, but when this ribbing continued for a couple of months, Laura turned to me in frustration and asked, “Can’t I just be good at my job?”

In 2018, the National Academies of Science, Engineering, and Medicine (NASEM) released a study on sexual harassment in the academic sciences entitled “Sexual Harassment of Women: Climate, Culture, and Consequences in Academic Sciences, Engineering, and Medicine.” The report reveals the shocking extent of gender-based harassment in the academic workplace.

Between 20-50% of female students in science, engineering, and medicine report experiencing sexual harassment. This number jumps to over fifty percent for women at the faculty level. The report further breaks down high-risk populations—women of color and LGBTQ+ individuals are more likely to experience harassment than white, heterosexual women.

In total this means that, excluding the military, women in academia are harassed at higher levels than in any other sector of society.

Harassment is not just unwanted sexual attention or sexual assault; it can be a culture of belittling comments or raunchy jokes. The most prevalent but most misunderstood form of sexual harassment is gender harassment. Gender harassment is described as “verbal and nonverbal behaviors that convey hostility, objectification, exclusion, or second-class status about members of one gender.” When I spoke with Kate Clancy, an associate professor of anthropology at the University of Illinois and co-author of the 2018 NASEM report, she had a more snappy way of putting it: “we call [gender harassment] the put-downs of sexual harassment, whereas unwanted sexual advances and sexual coercion are the come-ons.”

These put-downs are all around us—they’re insidious and difficult to articulate because they are so thoroughly normalized in our culture. The women who experience gender harassment and choose to speak up about it are labeled as “sensitive” and over-reactive. But gender harassment is sexual harassment. It is, in fact, the primary form of sexual harassment.

The NASEM report found that women are leaving science due to sexual harassment, and that jokes can be just as harmful to a woman’s career as more violent forms of harassment. The negative effects of gender harassment extend beyond the subject to witnesses, labs, and entire institutions. As the National Academies’ report states, “the net result of sexual harassment is therefore a loss of talent, which can be costly to organizations and to science.”

But why is gender harassment so damaging? “For most people [an unwanted sexual advance] is a rare event. I think for a lot of folks it’s easier to externalize it and say, wow, this guy is just…trying to date me or trying to make me feel bad,” says Clancy. “Whereas put downs are really easy to internalize because one, we don’t recognize them as harassment and two, they often end up making you feel like the problem is you.”

Gender harassment can be even more difficult to spot as a bystander. This was the case with Laura’s harassment—I absolutely laughed along with the group. Despite going to a women’s college, despite considering myself a “Good Feminist,” I didn’t even see what I was contributing to until Laura told me. I hadn’t considered the implications of the “joke” —that she hadn’t earned her praise, that she had been singled out as a favorite not because of her skill but because our principal investigator might be attracted to her.

In a way, Laura’s harassment was textbook—the harassment was coming from her peers (80% of gender harassment does). It was not a one-off joke, but instead lasted for a period of months (which, again, is common). And she didn’t feel there was a way to address the harassment, either through direct confrontation or an institutional route.

So what is it about academia that makes it so toxic for women and damaging to their careers?

One major factor is a culture of male dominance. This is easiest to understand in fields such as engineering and physics, where men vastly outnumber women. However in the biomedical sciences, where women have been earning more Ph.D.s than men for many years, the concept is more nuanced. Male domination in these fields refers to the fact that men generally hold higher positions than women, and that the field has historically been male.

Academia is also hierarchical. Institutions with a strong hierarchical power structure are more likely to foster sexual harassment. This is especially true when power is concentrated in a few individuals (for example, “superstar” professors), and those who report feel that revealing harassment will have lasting effects on their careers. The nature of our system causes students to rely heavily on the full-throated endorsement of their mentors—which leaves them little to no recourse if they wish to report inappropriate behavior.

The truth is academic science is highly competitive. People can be cruel to each other in all sorts of ways, due to professional jealousy, ambition, or just general stress. Everyone has an anecdote about being humiliated at lab meeting, or getting back an eviscerating review on a paper. Everyone has experienced some incivilities (officially defined as, “low-intensity deviant behavior with ambiguous intent to harm the target”).

Part of this is the broader culture of academia. “We tend to equate treating people like crap with being rigorous researchers,” Clancy points out. However, these incivilities are not evenly distributed; “There’s ample research that now shows, even though incivilities don’t seem to be gendered, they are actually quite gendered and racialized.…The folks that experience them most are typically women of color followed by white women, then men of color and white men,” Clancy says. Given that women and people of color also have their gender or race routinely used against them, it’s no wonder academia has a climate problem.

In the end, organizational climate is by far the best predictor of sexual harassment. Harassment flourishes where people who report it are perceived to take on risk, where there are no sanctions against perpetrators, and where reporters’ experiences are not taken seriously by their peers or institutions.

Sure, individuals harass. But that is a learned behavior that grows out of a culture of perceived ambivalence. Frequently an institution’s priority is “symbolic compliance,” which focuses on protecting the institution and avoiding liability, instead of ensuring the safety of its employees.

Any institution serious about the success of the women it hires must take decisive action to stamp out the toxic culture that dominates the scientific workplace. Without a concerted effort to reform the workplace, gender equality will always be a fantasy for the academic sciences.

It’s the accumulation of harassment over many years that causes lasting damage to women in science. I truly think that every one of Laura’s experimental successes was, at some point or another, reduced to “because he’s in love with you.” In a job that contains so much day-to-day failure, how horrible is it to take away the successes as well?

When Laura and I talked recently, she brought up one of the earliest, most formative experiences of her scientific career. She was a technician, straight out of college, and had gone to her professor to propose some experiments.

“Woah, watch out,” he said. “Girl scientist on the loose.”

Of course this affected the way she presents herself. Of course this caused her to think about how she is perceived by the scientific community. It was a joke. And it stuck with her.

In the end I moved on from the lab where I met Laura. She moved on too— out of science entirely.

I am a graduate student now. Recently, I received a small bit of positive feedback from someone I consider to be a mentor. Elated, I flounced into lab and showed the first person I ran into.

My labmate read it, and laughed, “he should have just asked for your number.”

Pets of Tri-I

Pooja Viswanathan

For this issue, Natural Selections interviews Fifi, the young cat who lives with first year graduate students here at The Rockefeller University, Sarah Cai, Lindsey Lopes, and Kathryn Eckartt. Fifi is extremely sweet and playful and I enjoyed our meeting. Please contact me if you have sweet, little nonhumans living with you. I’d love to meet them.

Pooja Viswanathan: How old are you? In human years?

Fifi: I turn one on June 14th! That makes me a teenager in human years, which my moms say makes sense because of my sometimes naughty behavior.

 PV: Is there a story behind your name?

F: The shelter that I was adopted from named me Fifi and the name stuck!

PV: What is your first memory?

F: I don’t remember a lot from when I was a baby, but the people at the shelter said that I was found as a stray in NYC when I was six weeks old, and some nice person brought me to the shelter.

PV: Who are your moms? When did you first meet them?

F: My moms are Sarah Cai, Lindsey Lopes, and Kathryn Eckartt. They adopted me last October. I met them while I was hanging out with a bunch of my kitten friends at the shelter, and it was love at first sight.

PV: How do they belong to the Tri-I community?

F: They are all first year graduate students at The Rockefeller University. Sarah just joined Titia de Lange’s lab, Kathryn is in Jeremy Rock’s lab, and Lindsey is still rotating.

PV: Where do you live?

F: I live in Faculty House. I don’t really know what that means, but I like to look out the window at all the cars on the FDR and York Avenue.

 PV: If you could live anywhere else in the world, where would you live?

F: Hmm, I’m a city cat, but I definitely wish that I could go outside! Maybe somewhere with a big yard and lots of birds to look at.

PV: What are your favorite foods?

F: I love snacks. Some of my favorites are cat treats, chicken, and black beans…but I’ll definitely try anything if you leave your plate unattended! Except veggies. I don’t like veggies.

PV: What is your favorite weekend activity?

F: What are weekends? Is that when the humans are home more? I like to hang out in my moms’ rooms and knock over things on their desks, dressers, or any flat surface. I also like to nap in the sun.

PV: Besides your moms, who is your favorite human in the Tri-I community?

F: I like pretty much everyone that I meet, especially if they give me snacks!

PV: Do you have a funny story to share with us?

F: Sometimes Lindsey dog-sits and one time I decided that I wanted to try out some dog food, so I jumped onto the bookshelf where the dog’s food was and knocked over the whole bag. I made a hole in the bag with my teeth so I could eat the food…dog food is yummy!

PV: Is there some way we can see more pictures of you on the interwebs?

F: Yes! Check out my Instagram @fifi_the_kitten.jpg

PV: If you could have any human ability, what would it be?

F: I would love it if I had opposable thumbs because then I could get into all the treat jars! My moms had to stop leaving treats out in plastic bags because I would chew through the plastic to get more treats when they weren’t looking.

The 73rd Annual Tony Awards

Melissa Jarmel

The 73rd annual Tony Awards will broadcast live on June 9th at 8 p.m. ET on CBS. James Corden is returning to host the show, so I expect the opening number this year will be as smart and delightful as his last. The full list of Tony nominations can be found here, but I wanted to highlight some of the new shows appearing on Broadway this year.

Aaron Sorkin wrote a play based on Harper Lee’s novel To Kill A Mockingbird that is currently being performed at the Shubert Theatre. This classic American story explores race and class in the South in the 1930s. If you’ve been a fan of Sorkin’s snappy dialogue and skillful rhetoric, you’d be remiss to skip out on this production even though it did not receive a Tony nomination for Best Play. This was a strong year for new plays on Broadway so it’s possible that a strange split vote resulted in this oversight, or rumor has it that it might have been an intentional snub due to the lawsuits that the production has been involved with that led to the shut-down of some community theatre productions. However, this production still accrued nine deserved nominations in other categories.

My favorite to win Best Play this year is The Ferryman, which transferred to the Jacobs Theatre from London last year. Jez Butterworth’s epic drama centers around the fictional Carney family in Northern Ireland. While exploring the often-complicated dynamics of family, Butterworth also weaves a compelling narrative about how the past traumas of a country can strangle a family’s progress for decades to come. It’s worth brushing up on 20th century Irish history before seeing this play to catch the meaning of references to historical events the characters discuss, but the interpersonal dynamics at play are also absorbing enough outside of the context of history. I didn’t check my watch once during this 3 hour 15 minute production (though there is an intermission).

I would also highly recommend Heidi Schreck’s What the Constitution Means to Me, which was a finalist for this year’s Pulitzer Prize for Drama. This play was inspired by her experiences as a teenager giving speeches about the U.S. Constitution for scholarship money. Heidi Schreck also stars in this play that explores how her understanding of the Constitution has evolved over time and the impact the Constitution has had on women’s bodies in America. Schreck does not shy away from talking about the specific traumas women in America have experienced as a result of past and current legislation, so a trigger warning is necessary.

Hadestown is the favorite to win Best Musical this year, but this is the only new musical nominated that I have yet to see so I don’t have a personal recommendation. However, I’ve heard great things about this musical adaptation of a folk opera concept album by Anaïs Mitchell that reimagines the myth of Orpheus and Eurydice. Ticket prices have recently soared for this show upon receiving positive reviews and Tony nominations, but they do offer a general rush and digital lottery.

All of the other nominees for Best Musical offer nostalgia or feel-good vibes, which may be reflective of what Broadway-goers need from art in today’s climate. Ain’t Too Proud—The Life and Times of the Temptations is primarily a jukebox musical that will have Temptations fans dancing in their seats, but the book is also deftly written to brilliantly convey the group dynamics at play during Motown’s heyday. Beetlejuice genuinely surprised and delighted me as someone who was not a fan of the movie. It’s very self-aware with a stunning set design, catchy music, and energetic acting from start to finish. I’d go see it again. I also still recommend seeing The Prom. But I hesitate to recommend Tootsie, a new musical comedy based on the movie from 1982. While I was laughing throughout this high-energy show with well-placed one-liners and brilliant acting, there was a part of me that was cringing and has cringed more as I’ve had time to process what I watched. For those not familiar with the story-line, a white, cis male who has a hard time finding work disguises himself as a female to get a job and drama ensues. The play seemingly acknowledges the problematic nature of this storyline throughout the show, but the tone in which the character presses on and faces minimal consequences lands a bit deaf. I guess I just don’t understand why we need another story right now about a white, cis male who pushes others around in order to get what he wants to only later justify it all in a self-congratulatory learning lesson for something everyone else has known for a while. But there were a lot of good jokes? Anyway, I think all of these productions will put on a good show for the Tony Awards so tune in on June 9th!

Natural Expressions

Music

Santa Maria Pecoraro Di Vittorio of the Rice laboratory at Rockefeller will be performing as a violist with the Chamber Orchestra of New York directed by Salvatore Di Vittorio at three events this month:

On June 6th at 7:30 p.m., the orchestra will perform Mozart’s Flute Concerto No. 2, Il Sogno del Cielo, and Mozart’s Symphony No. 40 in Weill Hall at Carnegie Hall. The evening will include the work of two Resphighi Prize winners—flutist Tommaso Benciolini and composer Andrea Montepaone. Tickets and more information can be found on the Carnegie Hall Web site, with tickets from $40-50 ($30 for students with ID) or 25% off with the discount code CNY29834.

On June 7th at 7:30 p.m., you can hear Santa Maria Pecoraro Di Vittorio and the orchestra perform works by Vaughan Williams at the Adelphi University Performing Arts Center in Garden City, Long Island. In addition to Williams’ Eighth Symphony and Piano Concerto, the orchestra will play John Barry’s “We Have All the Time in the World,” which James Bond fans will recognize from the movie On Her Majesty’s Secret Service. Tickets are $35 ($15 for students with ID) and can be purchased online.

On June 27th at the Cary Hall at DiMenna Center for Classical Music, the Chamber Orchestra of New York will host a special event “Respighi’s Ancient Airs and Di Vittorio’s Venus,” celebrating the orchestra’s recent recordings of two albums for Naxos Records. The night will begin with a an open rehearsal, followed by a performance that will include the work of Ottorino Respighi. The evening’s concert will be recorded and be followed post-concert reception with the performers, co-sponsored in part by Marchesi Antinori Wines and Antico Noe Panini of Florence. Tickets are $50 (21+) and can be purchased here.

Email Megan E. Kelley at mkelley@rockefeller.edu to submit your art/music/performance/sporting/other event for next month’s “Natural Expressions” and follow @NatSelections on Twitter for more events.

Life on a Roll

Blue Lagoon

Elodie Pauwels

https://elodiepphoto.wordpress.com/

Turquoise blue waters! How could you not fall for this lagoon and surrounding islands near Kissamos in Crete, Greece? To enjoy the warm transparent waters and light sand of Balos Lagoon, you need to earn it: be prepared to reach the spot by boat or by foot, and cope with the absence of shade. Then you can spend hours drooling over countless shades of blue.

Resilience: Bouncing Back and Moving Forward

Emily Atlas

 

Sharon Milgram, Photo Courtesy of NIH OITE

“To become a successful scientist you must be resilient.” A phrase like this may sound familiar or perhaps even trite. Most would agree that the path to a Ph.D. (or M.D.) requires the ability to cope with failure and to regroup, restrategize, and reenergize after setbacks. However, is resilience a trait that can be learned? If so, how?

In mid-March, Sharon Milgram, director of the National Institutes of Health (NIH) Office of Intramural Training and Education (OITE) gave a talk about “Becoming a Resilient Scientist.” The event was cosponsored by two organizations at Memorial Sloan Kettering: The Gerstner Sloan Kettering Women in Science and the Female Association for Clinicians, Educators and Scientists (FACES).

Milgram was an extremely engaging and entertaining lecturer who used her story-telling skills to impress upon the large audience of scientists and M.D.s the importance of self-reflection and subsequent intentional action to become more resilient. The graduate students introducing Milgram opened up the talk with a lighter mood, sharing that when Milgram had first applied to graduate school (with goals of becoming a professor of physical therapy), she was not accepted. When she applied again, she ended up enrolling in a cell biology program. Then, she had to take her qualifying exam twice (and delayed taking it the second time for fear of failing again). But now she has her own lab and leads the NIH OITE, a testament to the fact that failures or slow starts can be more than overcome.

Milgram began by asserting that we are all life-long learners, particularly as scientists, since we are often learning new techniques and working on new problems that require entering semi-uncharted (and often uncomfortable) territory. Milgram adapted a summary of the four stages of learning a new skill from management expert Ken Blanchard. When we first embark on learning something new, we are “enthusiastic beginners,” and generally have low competence but are very confident. We then move on to the “disillusioned learner” stage in which we are more competent, but lose confidence, perhaps because at this point, we are aware of how little we actually know. When we are at the disillusioned learner stage, we generally feel very uncomfortable. Here, it is key to be resilient and move forward in order to reach the stage Milgram called “cautious performer,” where our competence and confidence have both increased, and finally the stage of the “high achiever,” where we have mastered the skill at hand and hence are much more confident. As scientists, we are often cycling through these stages and it is key to remember that each stage is only temporary.

In order to keep moving forward when we are experiencing a time of low confidence, we have to acknowledge our emotions but not drown in them. Resilience is the ability to both adapt and grow through adversity. We must navigate through the obstacles with both “intention and skill.” Milgram emphasized that resilience can be learned, but only if we are willing to reflect on how we currently deal with adversity.

We need to learn to be resilient at a time when we aren’t facing major challenges, so that in the face of adversity we are prepared to tackle roadblocks. Milgram outlined a few steps we can take in order to become more resilient: First, we should try to learn from past experiences; journaling can be a good technique to reflect on times in which we have succeeded in moving forward and times we could have done better. Second, developing strong relationships with peers and mentors is key and helps to remember that we are part of a larger community; we are not in this alone. Third, it is crucial to use resources and be proactive. Every institution has resources available and we need to learn how to ask for help when we need it. In some cases, counseling is also an important resource for people to utilize. Finally, we should be thoughtful about how we approach setbacks in our lives and careers and become more mindful of the “self-talk,” often negative, that we engage in during times of setback.

Milgram then elaborated more on negative self-talk. Inspired by Marshall Rosenberg’s techniques of non-violent communication, Milgram asked us to imagine both jackals and giraffes (jackals conjuring up the image of vicious creatures, and giraffes, peaceful, graceful ones). After we fail at something, we often tell ourselves stories in “jackal” language, rather than “giraffe” language. Furthermore, the stories we tell ourselves are often far more negative than the situation warrants. We may experience cognitive distortions or automatic negative thoughts that make us feel hopeless. Our brain has a negativity bias, because being anxious and on high alert has evolutionary advantages, keeping us safe from danger. However, negativity can be harmful when we are not in danger, but are doing something new and uncomfortable.

Milgram delineated five types of negative self-talk, asking the audience to raise our hands if we identified with any of the five. The audience was filled with giggles at this time, as most people found themselves strongly identifying with at least one or two of the categories that Milgram described:

  1. All or nothing: We tell ourselves that if anything goes wrong, the whole endeavor was a failure.
  2. Catastrophizing: We exaggerate the implications of a failure and how it may affect a much bigger part of our lives or career.
  3. Mindreading: We make assumptions about what someone else is thinking (perhaps for example, after a conversation with a Principal Investigator). Milgram calls this a “special kind of fortune telling.”
  4. Minimizing: We downplay the importance of our accomplishments or positive qualities. This can also play into “imposter fears”—we tell ourselves “it was just luck.”
  5. Over-Generalization: We apply one negative event to others, assuming that because one thing went wrong, others will too.

To overcome these types of negative self-talk, the first step is to recognize and acknowledge them and then to talk back to them. Milgram suggests trying to think about our negative thoughts at a distance, thinking about how logical or scientific our fears and anxiety are, i.e., what evidence do we have to really back them up? Then, try to find inspiration from something positive, be it an affirmation, a phrase, even an image that strengthens you. Journaling and talking about our fears and anxieties is also very useful.

Pathway to resilience, Photo courtesy of American Psychological Association

The second part of Milgram’s talk focused on imposter fears, which are very common among students. People who fear failure, have perfectionist tendencies, and compare themselves to others are more likely to have imposter fears. External factors (such as messages from friends and family, or organizational culture) can also feed into imposter fears. Imposter fears are normal, but if unchecked they can seriously increase stress over the course of a career and ultimately result in self-sabotaging behavior, such as not applying for new opportunities or not studying. To overcome imposter fears, we need to normalize them by reminding ourselves that they are a common response to new situations, but we also need to find meaning in other aspects of our lives, so we are able to move forward and not let these fears hold us back. It is crucial to think about “what brings meaning to our days, months, years,” and ideally, we should find meaning in relationships or activities separate from our work; this helps us stay resilient. At this point Milgram addressed what she calls the “elephant in the room,” the fact that the culture in science and medicine doesn’t always value self-care, but she challenged us to fight against the culture and try to change it. At the end of her talk, Milgram summed it all up by reminding us that in order “to do well, we have to be well.”

Culture Corner

The Piero Tour in Italy

Bernie Langs

 

While familiarizing myself over the years with the pictures painted by the Masters of the Italian Renaissance, I have found that one artist stands out as singularly enigmatic in his body of work, Piero della Francesca (c.1415-1492). I have read various summaries about della Francesca in art history books and enjoyed Kenneth Clark’s detailed study where he analyzes how the artist’s few surviving works leave the viewer in a state of dumbstruck awe. I became deeply interested in the artist, after reading an essay by art historian Michael Baxandall which focuses on the visual tricks utilized by della Francesca in the “Resurrection” fresco and other ideas about its creator.

I first heard about “The Piero Tour” in early 2018 while vacationing in London. My wife and I had gone to see a performance of Oscar Wilde’s “An Ideal Husband” where we were glad to be among an audience mostly filled by natives of London or the United Kingdom, including to our delight the famous actor, Sir Ian McKellen. After the production, I spotted an impeccably dressed gentleman striding by holding the program booklet in his hand. I called out, “What did you think of the play?” initiating a twenty-five minute, robust discussion covering a wide range of cultural topics. When I mentioned the sublime collection of della Francesca’s major paintings I’d viewed that day at the National Gallery, the gentleman agreed that there is a mysterious quality to della Francesca like no other artist and he insisted that we must take The Piero Tour around Italy, centering on the city of Arezzo and surrounding smaller towns where the Master’s finest works are concentrated. In late 2018, my step-sister, Jen, was visiting New York from Milan with her Italian-born husband, Gui, and when I told them of our London conversation, Giu nodded and said, “Of course, The Piero Tour. I’ve done it and you have to go as well!”

Months later, I read a fascinating scholarly book by Professor Carlo Ginzburg who is currently teaching at University of California Los Angeles. In “The Enigma of Piero: Piero Della Francesca,” Professor Ginzburg combs through the historical record like an art history Sherlock Holmes to identify specific portraits embedded in della Fancesca’s frescoes and paintings and makes countless, detailed discoveries on the meanings of such masterpieces such as “The Flagellation,” which has defied narrative understanding for centuries. Professor Ginzburg also undertakes a complex deconstruction of the fresco cycle in Arezzo known as “The Legend of the True Cross.”

This March, my wife and I took a vacation in Italy, staying thirty minutes outside of Pisa in a quiet hillside area. We drove to Lucca, Siena, San Gimignano, and Pisa and enjoyed the art, food, and wine of Tuscany. When I had emailed Jen prior to the visit, she and Gui said they would meet us in Arezzo for a day trip, the plan being that they’d give us the truncated version of The Piero Tour.

Arriving in Arezzo on a brisk morning, the four of us made our way to the church of San Francesco to view della Francesca’s large set of frescoes, the above mentioned “Legend” cycle. The four of us stood in the uncrowded chapel space in awe, raising a pointed finger now and then to share the discovery of an unexpected detail. Most of our time in San Francesco was spent silently ingesting the power and beauty of this wonder of the world.

“The Legend” frescoes are a high point of Italian Renaissance art. The cycle is centered a thirteenth century tale of how the wood from the Garden of Eden was eventually used to construct the cross on which Christ was crucified. The Bacci family in Arezzo commissioned it in the mid-1440s and it was most likely completed in 1466. Scenes depicted in the upper registers include “The Queen of Sheba in Adoration of the Wood,” “The Meeting of Solomon and the Queen of Sheba,’ “The Death of Adam,” “Exaltation of the Cross,” “The Dream of Constantine,” and “Battle between Heraclius and Khosrau.” Professor Ginzburg’s book on della Francesca explains the meaning of these works, noting that the frescoes display events with Old Testament figures as well as those who lived in the pagan world at the rise of Christianity, such as Constantine the Great prior to his conversion to the new faith.  Ginzburg also describes how the Legend cycle depicts tensions, both religious and political, in the mid-fifteenth century Eastern and Western worlds of Europe and beyond, by pointing out in one example, that the portrait of Constantine the Great in the frescoes is none other than John VIII Palaiologos who served as the penultimate reigning Byzantine Emperor, ruling from 1425 to 1448. The emperor’s portrait is used to similar ends in della Francesca’s painting of “The Flagellation.” It is suggested by Ginzburg that those in the circle of della Francesca’s patrons knew and had met with Palaiologos.

Ginzburg explains why della Francesca chose certain real-life individuals for portraits strategically placed within the frescoes, discovering that these faces recur in other smaller paintings by the artist and with similar discrete intentions. But much of what I’d read slipped away from me while marveling at the art in San Francesco that morning. The beautiful colors of the landscape, garments, and skin tones are muted and reassuring, especially the blues and reds. Later in the day as we drove around the area, the cloud cover receded and the blue sky overhead taught me more about della Francesca’s eye and brushstrokes than anything one could read in a book. The sublime skies of his paintings singularly match those viewed in Arezzo.

The men and women depicted by della Francesca in “The Legend” frescoes exude an inner quality of delicate grace and refinement. As we continued through the day, I noticed this aspect in other paintings by him and many others of the region. Regardless of whether you buy into established Christianity or not, the paintings often teach a lesson on the finest qualities of mankind’s soul. Depictions of the so-called “higher” human attributes through the brush or by the chisel in statues, make them more than a fanciful display of the talent of an artist. This art acts to encourage us all to do better, be better people, and to think better of each other and our higher potential in life. Centuries-old divine attributes displayed by posed, static, artificially-created individuals, stories, or landscapes, can offer nothing short of essential life lessons that even my fellow hardened agnostics and atheists should gladly embrace, stripping away the religious context and retaining the best of the rest.

Leaving San Francesco, the four of us made our way to Arezzo’s cathedral, where Gui led us briskly down an aisle to stand before della Francesca’s more obscure fresco from 1460 depicting Saint Mary Magdalene. Mary’s garments are painted with simple, subtle tones, and her features, though individual, display della Francesca’s standard facial physiognomy, the broad nose, full lips, and heavy-lidded eyes, which may express anything from fatigue to resignation or perhaps a quiet inner state of enlightenment. “The Magdalene” was an overwhelming joy to behold and it felt very special to be in its presence in the magnificent cathedral.

We next drove to the Museo della Madonna del Parto located in the nearby town of Monterchi. della Francesca’s “Madonna del Parto” was most likely produced after 1457 and it only survives as a fragment. The fresco survived an earthquake in the late 1700s and has moved multiple times. The Museo has a nicely presented short film explaining the complex meaning of the work and gives detailed geometric graphics of how the master’s placement of the Madonna and two attending angels are set with mathematic precision. The “Madonna del Parto” is on view in the Museo as the only work in a small, white-walled room. It’s a beautiful painting of the pregnant Virgin, yet I was very much distracted by the modern setting. Much of its power and meaning was lost to me by not seeing in situ in a Gothic or Renaissance church among other surviving statues, frescoes, altar works, and paintings from the time period. I couldn’t make total sense of the art in its fragmented state, and could not coalesce an aesthetic or emotional reaction into some kind of whole.

We continued the tour by driving to the town of Borgo Santo Sepolcro (Sansepolcro), where della Francesca was born and where we later toured his unexpectedly large family home in the city. Sansepolcro was alive with Medieval and Renaissance reverberations all over its joyful streets. Two major works by the artist are on view at the Museo Civico de Sansepolcro, “The Polyptych of the Misericordia” and the extremely famous “Resurrection.” The oil painting of the former centers on the motif of the Virgin of Mercy. The Museo Civico is a more traditional museum than the one housing the “Madonna del Parto” and the “Misericordia” maintains an incredible power and force on viewing. After studying the painting for a long period, I suddenly recognized from Professor Ginzburg’s book the figure kneeling on the far left beneath the Madonna as della Francesca’s patron, Giovanni Bacci, who also commissioned with his family “The Legend” cycle in Arezzo. The mystery of della Francesca and his overwhelming power was stronger in the “Misericordia” than in any other we viewed that day. The central panel and its surrounding smaller pieces, as well as the predella (the smaller panels at the base of an altarpiece) and the tympanum (the pediment panel pictures above the main images) sweep deep to the mind’s interior defying translation into words or emotional adjectives.

“Resurrection” was painted in the 1460s for the city’s Town Hall, which is now the Museo Civico where it remains, though not in its original room. The detached fresco is displayed on a wall in a large space, which was undergoing renovation. It was the only work of art on view besides two small fragments that were reproductions of frescoes that are out on loan. I’d waited decades to see the “Resurrection” and although it was remarkable, once again, to view it in a white-walled space and not in a church or even with its artistic “family” of paintings in a museum, distorted my attempted meditation. In any case, it was incredible to actually see in person the well-known sleeping Roman soldiers, including a supposed self-portrait of the young della Francesca. The mysterious landscape background, half-alive in foliage and half-dead, is haunting. The image of Christ, climbing out of the sarcophagus in defiance of death elicited an odd reaction from me. Perhaps through a fault of memory of the reproductions in books, I had expected Christ to look fatigued and weak, but found his large body muscular in tone and in an almost inappropriate state of power given his recent trauma. I hope to return one day to the Museo to take more time studying this invaluable work of art.

During our visit, we took a detour to visit a small church built on the remains of the building where Saint Francis of Assisi retreated at times for meditation in the thirteenth century. The complex is embedded in the mountains of the area and in contrast to the countryside my wife and I had driven through during our stay near Pisa; with manicured, rolling hills speckled with graceful cypresses and other trees, this was a semi-wild, rolling forest and the view from the church revealed no other structures in sight. There were a couple of cars at the site, but we saw no other person inside or outside the tiny buildings. The view was spectacular, and out of nowhere we were joined by a friendly cat, who later accompanied us up the hill and back to our car. I joked that it was the ghost of the Saint, noting the irony that the man who had famously preached to the birds was now a feline.

After a relaxing dinner in Arezzo, we walked the dark streets towards the arches in the old walls leading to the car park. The wind and cold picked up and we were the only four people on the last cobblestone street lined with old stone buildings from the Middle Ages. Flags flying above rippled and crackled in the wind, and as we passed a sculpted display on the walls depicting the coats of arms of the old families of Arezzo, I mused that these statements of civic pride had stood there for hundreds of years and would be there for hundreds more. As my wife and I parted with hugs and smiles from our gracious guides, Jen and Gui, I was warmed by the idea that I’d had one of the best days of my life.

Piero della Francesca, “The Legend of the True Cross” (details), c. 1452-1466, Basilica of San Francesco, Arezzo

Piero della Francesca, Saint Mary Magdalene,1460, Duomo, Arezzo

Piero della Francesca, The Polyptych of the Misericordia (detail), c. 1460-1462, Museo Civico di Sansepolcro

Madonna del Parto (after 1457), detached fresco, Museo della Madonna del Parto, Monterchi

Piero della Francesco, Resurrection and detail of possible self-portrait of the artist, center, Museo Civico di Sansepolcro

Mountain retreat near Monterchi visited by Saint Francis in the 1200s with his “ghost” appearing as a friendly cat

Pets of Tri-I

Pooja Viswanathan

 

For this issue, Natural Selections interviews Malu, the dog who lives with Tiago Siebert Altavini (Gilbert Lab, The Rockefeller University) and Patricia Saletti. Malu speaks Portuguese and I only know 10 words of it, but her parents were willing and capable translators for our interview. I love animals, please write me at pviswanath@mail.rockefeller.edu if you have pets!

Pooja Viswanathan: How old are you? In human years?

Malu: I’m 5, which in human years is about 36 years old.

 

PV: Is there a story behind your name?

M: Malu is actually short for Maria Luiza, which my parents only use when they are mad at me. That doesn’t happen often though.

 

PV: What is your first memory?

M: I’ll never forget the day I met my best friend, Nina. She lives with my grandparents and we spent much of our childhood together. We used to play a lot in the backyard. Unfortunately, I don’t see her much anymore because she lives in Brazil and I live here.

 

PV: Who are your parents? When did you meet them?

M: I live with Patricia and Tiago, my mom and dad. I met them in August 2013 when I moved in with them.

 

PV: How do they belong in the Tri-I community?

M: My dad works in the Gilbert lab as a postdoc. My mom is also a postdoc but works far away in the Bronx, but she has many friends in the Tri-I community.

 

PV: Where do you live?

M: I live in Scholars Residence, the tall building close to the university where my dad works.

 

PV: What are your favorite smells of New York City?

M: Oh, I love to smell everything. My mom always complains that we take too long when we go for a walk. I guess that’s why my dad does most of the walking with me.

 

PV: If you could live anywhere else in the world, where would you live?

M: Definitely in Brasilia so I could be close to my best friend, Nina. But I have to say I would be tempted to live closer to the beach. I love the beach, it’s like a huge dog park with all that sand.

 

PV: What are your favorite foods?

M: Chicken and carrots! Not necessarily together. I usually get chicken flavored dog food and whenever my dad is cooking I cry by the kitchen countertop to see if he’ll give a little piece of vegetable. If I hear him cutting carrots, I come running. I also like to eat fruits.

 

PV: What is your favorite weekend activity in New York City?

M: Going to the dog park. I don’t care much about the other dogs to be honest, but I get to play “catch the ball” a lot, which is my favorite game. I don’t go much anymore though. I got sick after going to one of these parks and now my parents are afraid of taking me again. I also like going to Central Park and to the beach.

 

PV: Besides your human roomie, who is your favorite human in the Tri-I community?

M: I have many friends in the area, but if I had to choose one, it would be Sofia from the Freiwald Lab. We used to be neighbors and I would play with her all the time. I usually stay with her when my parents are out of town. We play a lot and she teaches me Spanish.

 

PV: Do you have a funny story to share with us?

M: I tend to get very excited after my morning walk. When I come back from walking, I run around the house, play with my toys and try really hard to get everyone’s attention. One day I was particularly agitated and decided to jump on the bed. Now, the bed is too tall for me, but on that day I was feeling so energetic I was sure I could do it. I took some distance, ran towards the bed, jumped and hit the side of the bed with my chest and fell to the floor on my back. I didn’t get even close. I didn’t find it too funny at the moment but my parents laughed the whole morning.

 

PV: Is there some way we can see more pictures of you on the interwebs?

M: No, my parents say I’m too young for social media.

 

PV: If you could have any human ability, what would it be?

M: To open the door and go out by myself. I love going out, to the park, to parties, to trips. The problem is sometimes my parents don’t take me with them and I have to stay home by myself until they come back.

Natural Expressions

Music

On May 10th, Collette L. Ryder of the Office of Sponsored Programs Administration at The Rockefeller University will be performing Rachmaninoff Vespers (All-Night Vigil, Op. 37) with the NYCHORAL group at St. Bartholomew’s Church. The New York Choral Society describes Rachmaninoff’s 1915 work as “quiet, reflective, and deeply moving…a majestic work that elevates the spirit by its expressiveness and captivates the listener with its sheer beauty.” The performance begins at 8 p.m. and discounted tickets ($35) are available by contacting Collette (cryder@rockefeller.edu / x8054). Visit NYCHORAL for more information.

 

Digital Events

Bernie Langs of The Rockefeller University Development Office announces the release the music video, “Yeast Cell Growth Meets The Beatles.” This video, presented by John LaCava’s Sounds of Science and featured in the Imagine Science Film Festival, is a fusion of art and science, with laboratory films taken by Andrej Ondracka and music by The Beatles (composed by John Lennon/ Paul McCartney with a coda by Chip Taylor) performed by Bernie Langs. The video can be found on Bernie Langs’ YouTube page.

 

Email Megan E. Kelley at mkelley@rockefeller.edu to submit your art/music/performance/sporting/other event for next month’s “Natural Expressions” and follow @NatSelections on Twitter for more events.

Life on a Roll

Perspective

Elodie Pauwels

https://elodiepphoto.wordpress.com/

Perspective makes parallel lines look like they will join somewhere in the distance. The laws of geometry seem thrown into disorder! This distortion however only exists when the scenery is observed from a particular point of view. These kinds of pictures are an invitation to discovery and travel for me. What about you?

Geometrical corridor, Angoulême, France

Railway, Breda, The Netherlands

The Majesty of Cathédrale Notre-Dame de Paris

Jim Keller and Dom Olinares

Following the devastating fire on April 15th, let’s take a minute to remember how the Notre-Dame Cathedral in Paris was meant to be seen, in all its magnificent glory. These photos were taken during our trip to Paris last year.

As we watched the flames engulf the Cathedral on the news, including its timber central spire, we felt helpless. Our hearts ached for France and for the world.

Although the cause of the fire is still unknown, on April 16, the Paris prosecutor said that nothing his office had learned suggested a deliberate act. The investigators most strongly suspect a case of “accidental destruction by fire,” but they have not ruled anything out at this early stage.

Whatever the cause may have been, in the words of French President Emmanuel Macron: “We will rebuild Notre-Dame together.” Less than 24 hours after the fire had broken out, over €800 million had been pledged for the Cathedral’s reconstruction. True to his word, an international fundraiser was launched by Macron the very next day.

Please visit http://www.notredamedeparis.fr/ for more information.

 

Natural Selections Interviews Rockefeller’s Viviana Risca

Natural Selections Interviews Rockefeller’s Viviana Risca, Principal Investigator of the Laboratory of Genome Architecture and Dynamics

Alice Gadau

Viviana Risca, photo by Alice Gadau.

At the age of fourteen, Viviana Risca spent her summer break unlike most teenagers. Every morning, she took the train from Long Island to work in Dr. Daniel Eichinger’s parasitology laboratory at New York University. Despite the cabinet full of dead worms in formaldehyde she had to pass every morning, this first exposure to biological research was highly influential in propelling her into a lifetime of research. Since then she has been excited about using molecular techniques to understand the processes that occur in cells.

Viviana has now joined the Rockefeller community as one of the two new tenure-track assistant professors hired in 2018. After completing her Ph.D. in Biophysics at the University of California, Berkeley, she continued her scientific career as a postdoctoral scholar at Stanford University with Professor William J. Greenleaf. Viviana is interested in the biophysical rules that contribute to the dynamics and stability of the genome. In addition, she wants to understand how the three-dimensional genome architecture can regulate DNA-based processes.

Alice Gadau: What is the central question you are trying to address in your lab, and how is this an expansion from your past work?

Viviana Risca: The three-dimensional structure of the genome is controlled by its association with a variety of proteins, together making up a DNA-protein complex we call chromatin. Through the efforts of large-scale sequencing projects, we now know much of the linear sequence of bases that make up the human genome, but we are still far from fully understanding the mechanisms that control how and when the information encoded in DNA sequence is read out by transcription. A skin cell and a muscle cell contain the same genome, but they express different sets of genes that give rise to their unique identities.

My lab seeks to understand how three-dimensional chromatin structure controls the ways in which various proteins, including those involved in transcription, access their binding sites on DNA in order to perform their biological functions. One of the driving hypotheses of our work is that chromatin structure acts as an integrator of many molecular inputs to modulate access to DNA. I am particularly interested in how chromatin modifications, inter-molecular interactions, and polymer effects give rise to specialized parts of the cell’s nucleus that stably repress transcription and help maintain cell identity and normal cell function. Both chromatin structure and the processes that shape it are often perturbed in cancer, as well as during aging, and I hope that our work on these fundamental processes will provide useful leads toward better cancer therapies and diagnostics.

As a postdoc at Stanford, I worked on exploring how the landscape of enzyme-accessible chromatin can give us insights into the regulatory networks that control gene expression in several cell types, including a cancer model, using a popular method called ATAC-seq. I also did a lot of technology development, which resulted in RICC-seq, a method for mapping chromatin fiber structure at high resolution, and ChAR-seq, a method for mapping contacts between RNA and DNA genome-wide. In my own lab, we will continue to use and develop these technologies, applying them toward the goal of understanding the basic biophysical and molecular mechanisms responsible for stable transcriptional repression and overall control of access to genomic DNA.

AG: How does three-dimensional genome architecture contribute to DNA regulatory processes?

VR: Since the 1920s when Emil Heitz coined the terms euchromatin and heterochromatin, we have known that the cell nucleus is divided between regions of high and low chromatin density. Since then, we have learned that organization of chromatin is far from random—it is in fact organized at multiple length scales.

At short length scales, every 150-200 bp of eukaryotic genomes is wrapped around roughly 10 nm-wide histone complexes called nucleosomes. Regions of DNA that are depleted of nucleosomes tend to be hyper-accessible to exogenous enzymes we use to probe them, and we interpret these regions to be also accessible to endogenous proteins like transcription factors, chromatin remodelers and polymerases. Indeed, many of these proteins seem to localize to nucleosome-depleted DNA. We also know that some histone modifications, like lysine acetylation, is associated with low-density, euchromatic regions of the genome that tend to be more accessible to protein binding. The high-density, heterochromatic parts of the genome are less well understood, from a structural standpoint, and many labs, including my own, are currently trying to decipher the mechanisms that drive the exclusion of transcriptional machinery from these silent genomic regions. Candidate mechanisms that have been proposed include occlusion of binding sites by DNA buried in compacted chromatin, chemical exclusion by phase-separated liquid domains, and simple volume exclusion from high density regions.

We also know that there is functional communication between genomic regions at much longer length scales spanning tens of thousands and sometimes hundreds of thousands of kilobases. Enhancer elements in the genome, which are acetylated, hyperaccessible, and bound by transcription factors when active, somehow must communicate with gene promoter regions because they regulate these promoters. This is thought to happen via DNA looping interactions in three dimensions, but the exact nature and dynamics of these contacts are an active area of research and not yet understood. Lastly, we also know that the cell nucleus is divided up into regions with different functional profiles, through associations with the nuclear lamina or self-association of potentially phase-separated domains like the nucleolus. How this long-range organization relates to short-range chromatin folding is also an area that my lab plans to explore.

AG: What is RICC-seq and how can it accurately examine short range DNA contacts?

VR: RICC-seq stands for ionizing Radiation-Induced Correlated Cleavage. In the 1990s, it was shown that the pattern of DNA damage induced by X-rays or gamma-rays on a cell’s genome is shaped by the way the DNA is folded into chromatin. RICC-seq takes advantage of this convenient property of chromatin. We irradiate cells with X-rays or gamma rays, carefully extract the short pieces of resulting single-stranded DNA, and then sequence those pieces. Their ends tell us about the pattern of DNA damage and consequently, about the way the DNA was folded in the original cell. This method works well for mapping high-resolution DNA-DNA contacts on the order of less than 10 nm and less than a thousand base pairs, making it complementary to other three-dimensional structure mapping methods like Hi-C, which work better for contacts spanning thousands of kilobases.

AG: What makes RICC-seq novel from other sequencing techniques?

VR: RICC-seq has two unique advantages. First, it can be performed on living cells that are not fixed or permeabilized. Therefore, we can probe chromatin structure in its native state. Second, it uses hydroxyl radicals generated by radiation as its probe. The radiation can penetrate all areas of the nucleus, no matter how dense, and the radicals are smaller than water and can easily diffuse. Therefore, we can get data from not only the low-density euchromatin in the nucleus, but also from highly compacted, dense heterochromatin.

AG: What other tools are you incorporating in your lab to understand genome architecture?

VR: RICC-seq is not a single-cell method and requires quite a bit of input material, so we will be combining it with lower-input methods like single cell or bulk ATAC-seq and RNA-seq, as well new cutting-edge technologies as they emerge. We will also be complementing this work with protein binding measurements like ChIP-seq or CUT&RUN, and microscopy that can tell us about the long-range organization of the nucleus. Lastly, we will also be collaborating with chromatin engineers to develop perturbations that will help us dissect causal and functional relationships between molecular factors and chromatin structure.

AG: Are there other hobbies you have that incorporate science?

VR: I’ve long loved incorporating skills that I pick up in the lab into my other hobbies. When I learned microscopy and optics, I also took up photography in my spare time, because the basic concepts are the same. I love art in general and see a lot of parallels between the lives of scientists and artists. We are both seeking fundamental truths, and both need to continually find ways to nurture our creativity. I also love to cook. I often use it to relax because it uses many of the same skills as biochemistry or molecular biology, but you can usually determine failure or success more rapidly than at the bench, and it is also easier to share your successes with your friends.

Lastly, I love science outreach and communications, but I would not call those hobbies. I think all of us as scientists have a responsibility to share our work with the public that, after all, supports our work through taxes and donations, to advocate for the societal benefits of basic research, and to equitably educate the next generation.

With a Schmear

Aileen Marshall

Assorted bagels, photo credit: unemployedeater.com

Bagels with lox, photo credit: Stu Spivak

New York City is known for many things—culture, nightlife, and food, to name a few. We already know about the widely recognized style of New York pizza and hot dogs. But did you know that the city is known for having the most authentic bagels? You can now get one anywhere, from a mass produced bagel in your local grocery store (generally not recommended) to many bakeries, delis, and restaurants around town, however they weren’t always so widely available. Where did bagels come from?

Various ancient cultures had some form of a bagel-like bread. There are Egyptian hieroglyphics that depict everyday people with round shaped bread with a hole in the middle. The design makes for even cooking and allows for easy transport, since many can be carried on a stick or a string. The bagel as we know it probably evolved in Eastern Europe, particularly Poland, in the Middle Ages. The earliest mention of a bagel in writing was from 1610 in the “Community Regulations” of Krakow. There is a legend that they were invented in 1683 in honor of the Polish king Jan Sobieski for saving Austria from Turkish invaders, but the earlier mention casts doubt on the story.

Bagels came to this country with Eastern European immigrants in the late nineteenth century. By 1900, there were seventy bagel bakeries on the Lower East Side. In 1907 the International Beigel Bakers Union was founded, which had the effect of limiting production mostly to this city. As these immigrants assimilated and moved across the country, so too did the popularity of and demand for bagels. Murray Lender, a Polish immigrant, opened a wholesale bagel bakery in New Haven, Connecticut in 1927, one of the few outside New York at the time. A turning point came in 1956, when the Lenders bought a freezer. They soon realized they could ship frozen bagels to distant retailers without them going stale. Today bagels are common in supermarkets, but Lenders’ bagels are the only mass produced bagels that retain authenticity.

By tradition, bagels are made by letting the shaped wheat-based dough sit for twelve hours at a cool temperature, around 40˚ to 50˚ F. Then they are boiled for about a minute before they are baked.  It is the boiling that gives them the sheen on the crust. True bagels have a dense chewy texture with a crust that has a slight snap when bitten. They should have absolutely no resemblance to white Wonder Bread.  Some say that New York City water gives bagels a better taste. According to the Smithsonian, the ratio of calcium to magnesium in our water binds with the gluten in the dough to give the bagels the accurate degree of chewiness.

Bagels come in different flavors including onion, sesame seed, poppy seed, cinnamon raisin, pumpernickel, rye, whole wheat, and egg. An “everything bagel” has some combination of these ingredients, having evolved from bakeries trying to use up all the dough they had left over. Bagels can be eaten as is or toasted, and usually topped with either butter, cream cheese (a schmear), jelly, lox, tomatoes, onions, capers, or some combination of these.  Around Saint Patrick’s Day, you may see some bagels dyed green. Different cities have their own style of bagels. In Chicago bagels are not boiled but baked with steam, giving them a very soft texture. Montreal’s bagels have dough containing malt and sugar but no salt. Honey is added to the boiling water for a sweeter taste. In London, bagels are smaller with a courser texture and more air bubbles. Since there is no legal regulation, many companies produce what they call “bagels” that are very far from the real thing.

Here in New York City, there are several famous bagel places as well as many smaller neighborhood establishments. The most familiar are Zabar’s, Russ and Daughters, the Second Avenue Deli, and Ess-a-Bagel. Another well-known store, H&H Bagels, is characteristically New York in that it was founded by a Puerto Rican family. The closest source to our university is Bagelworks, on First Avenue at 66th Street. So enjoy a typical city Sunday morning tradition and pick up the New York Times and a couple of bagels with a cream cheese and spend the rest of the morning relaxing with them.

Culture Corner

Celebrating the 50th Anniversary of Beggars Banquet by The Rolling Stones

Bernie Langs

Inner Sleeve of Beggars Banquet, photo by Michael Joseph.

In December of 1968 The Rolling Stones released Beggars Banquet just months before they would be introduced as “the greatest rock and roll band in the world.” The record, which features tunes by the songwriting team of Mick Jagger and Keith Richards at the very peak of their creativity, has a consistent, unified sound. Richards’ guitar work on Beggars ranges from nuanced and subtle to in-your-face, airplane engine electric power chords, ringing out and enveloping Jagger’s vocals in a cocoon of creative textures. Charlie Watts on drums and Bill Wyman on bass anchor all of the music with exactitude and precision. The band’s fifth member, Brian Jones, was fading away at the time of recording into an introverted state of confusion and a paranoid drugged out haze. Jones only contributed here and there, his last gasp of what he did best as a musician, putting the cherry atop the sweet sundae of the Stones’ tracks. It would be his final album as a Stone, as he was asked to leave after the record was completed so the group could bring in virtuoso guitarist Mick Taylor. Just a month after exiting the band, Jones died, drowning in his swimming pool.

Beggars Banquet was the first Stones album produced in the studio by the late Jimmy Miller. Miller would go on to work with The Stones on their finest albums, including Sticky Fingers and Exile on Main Street. Glyn Johns served as the studio engineer on Banquet and Nicky Hopkins provided piano for the band, shining on these tracks with his individual style. The late Hopkins may have been the greatest keyboardist who served as a hired hand for any major popular music band.

I was eleven years old when Beggars Banquet was released in America. My siblings and friends all knew that this record was something special, appearing a year after The Beatles released their genius LP, Sgt. Pepper’s Lonely Hearts Club Band. Nothing on Beggars was similar to Pepper’s. The compositions penned by Jagger and Richards remained rooted in the chord structures of traditional blues and also continued the Stones’ extrapolations on Chuck Berry’s “1-4-5” structure of early rock and roll composition, a pattern also derived from the blues. Lennon and McCartney’s songs on Pepper’s dazzle in experimental melodic complexity amid George Martin’s nuanced production. Martin and The Beatles would selectively celebrate their tracks with orchestral strings and woodwinds when the moment called for it. In contrast, the Stones stayed minimalistic on their records and could easily move from studio to stage with their tunes centered around two guitars, bass, drums, and piano, with small horns thrown in at times for variety.

Beggars kicks off with the infamous “Sympathy for the Devil” which was viewed in 1968 as reflective of the Stones’ image of danger and dark mystery. Even in my youth, however, I was intrigued by the serious nature of the lyrics and how deeply poetic they were in contrast to a lot of throw-away songs at the time. As Jagger steps into the guise of Lucifer, he’s more Oscar Wilde’s horrific gentleman Dorian Gray than a horror flick notion of the Devil. The character takes the listener on a tour of mankind’s violent history and sings with intensity as he describes his role both as observer and bloody instigator. The song’s exotic descriptions include gems such as “I lay traps for troubadours who get killed before they reach Bombay” and “I watched in glee as you kings and queens fought for ten decades for the gods they made,” which may be the only reference in pop and rock music to The Hundred Years’ War. Lucifer is a “beggar” who demands sympathy for what he’s watched us do and what he has had to endure. Yet he also threatens that “if you meet me have some courtesy, have some sympathy, have some taste; use all your well-learned politeness, or I’ll lay your soul to waste.”

Jean-Luc Godard, the French New Wave director, filmed the Stones recording “Sympathy” and put some of the footage in his movie “Sympathy for the Devil.” I find that movie ridiculous and unwatchable and wish someone would extract the footage of the band, add moments that didn’t make the final cut, and release it on its own (note that director Peter Jackson is currently taking the best parts of footage of The Beatles’ mess of a 1970 documentary “Let It Be” and adding many new scenes of them playing that were left on the cutting room floor). Godard captures how the band began with Mick Jagger strumming “Sympathy” on a guitar and how after some standard arrangements, the piece shifts to the heavy percussive Latin background sound, which is heard on the album. The congas and drums conjure the devil like Shakespeare’s witches brewing evil tidings from a boiling kettle. The song builds to a frenzy and fades away with the singer’s echoing falsetto cries as Lucifer spirals downwards to hell—the band plays furiously amid Richard’s sharp lead guitar work knifing through the mix. Lyrically, the words have more in common with England’s grand poetic tradition than the good vibrations and flower power anthems spilling out on the radio at the time. If Bob Dylan can win the Nobel Prize in literature for his groundbreaking lyrics, Jagger and Richards surely qualify as Britain’s Poet Laureates.

Beggars has fabulous moments of acoustic guitar-centered songs. After “Sympathy” fades out, the next tune is “No Expectations,” a Jagger and Richards song that mirrors the classic “Love in Vain” by American bluesman Robert Johnson. The Stones would record “Love in Vain” for their next album, Let it Bleed and while Johnson’s tune is about unrequited love and features images of trains leaving the station with one’s lost lover, the narrator of “No Expectations” is broken-hearted and requests in the opening lines, “Take me the station and put me on a train, I’ve got no expectation to pass through here again” and ends with a similar plea to be sent off far away in an airplane. The song’s narrator describes the fleeting nature of the love he’s lost, “like the water, splashing on a stone” and notes, “Our love is like our music—it is here and then it’s gone.” Brian Jones plays a wicked slide acoustic guitar, which resolves on an “open” E chord that Keith Richards must have been awed by, even through his anger with Jones’ continual drugged out confusion.

The best acoustic performance on Beggars is, “Prodigal Son,” written by Robert Wilkins, a reverend who recorded in the 1920s and 1930s. I’m not certain how old I was when I realized that the story of the song is Biblical, the famous tale of the arrogant youth who leaves home to find the world a harsh, punishing place and later crawling back to his father for forgiveness. Jagger singing affects a Southern, African-American spiritualist tone and Richards’ acoustic chords and lead flourishes are passionate and heartfelt. After Jagger’s last line, “My son was lost but now he is found” you can hear Richards give a guttural cry of “Hey!” as he brings it on home. One may venture that Mick and Keith would be absolutely content each day to sit on a porch in Mississippi in the summer sun, playing guitars and singing songs while swigging moonshine from a jug.

The rock songs on Beggars are fantastic, especially “Parachute Woman” and “Stray Cat Blues.” “Stray Cat Blues” in particular is an example of the Stones’ swaggering sexuality. When I was teaching myself guitar as a teenager, I would tune up to Beggars to play along with the album, and the rhythmic intensity of “Parachute Woman” was difficult to master. When I finally got it down, it was almost as if the guitar took over in the song for itself, and the intensity of the trancing repeating riffs brought me to a plane of surprising joy and newfound release. I could never truly master Keith’s leading stabs in “Stray Cat Blues” but Jimmy Page would give them homage on Led Zeppelin’s final album, “In Through the Out Door”.

The greatest masterpiece song on Beggars is “Street Fighting Man.” It is a slice of English history in living color, summing up the frustration of being a young man with energy and new ideas in 1960s London. It speaks of revolution, revelation, rebellion, and resignation all in one set of lyrics. Even if youth should run rampant through the city streets and “kill the King” they will ultimately be reduced to nothing more than bit players in a culturally limited rock and roll band. The sound of “Street Fighting Man” is the most complex in terms of instrumentation on Beggars. Charlie Watts and Keith Richards recorded their initial drums and acoustic guitars on a cassette recorder and Jimmy Miller manipulated that sound to abstract perfection. Additional guitars, percussion, and piano were added later and Brian Jones contributed well-placed drones on a sitar. Jaggers’ vocals are menacing, multi-tracked, and startlingly direct. I’ve listened to the song for fifty years and it is fresh on each hearing.

Beggars closes out with a beautiful song “Salt of the Earth,” an ode to the working class men and women of Great Britain. At the same time, in the song’s middle break Jagger admits that while on stage performing, the crowd is nothing but a “swirling mass of grays and blacks and whites” that don’t seem real to him and are actually “strange” in his eyes. The song hits a galloping peak and they give pianist Nicky Hopkins the honor of having it fade out to his manic right hand banging out a set of rapid chords.

The album’s release was delayed in 1968 because the record companies in America and Britain balked at the LP’s cover art of a dirty public bathroom with graffiti about the Stones and the songs on Beggars. It was eventually released with a white cover and a mock invitation to the banquet. The inner sleeve, however, boasts a black and white photo with shades of muted colors of the Stones celebrating like peasants who have invaded the King’s table in the Dark Ages. It may be the greatest match of image and personality in a band in the history of rock music, a fitting idea for an incredible piece of music.

Pets of Tri-I

Pooja Viswanathan

In this issue, Natural Selections interviews Muffin and Velvet, the cats who live with Sarah Mereby (Fuchs Lab, The Rockefeller University) and Eddie Spencer. I wasn’t able to meet these lovely creatures but Sarah graciously transmitted my questions to them and their answers to me. Please write me at pviswanath@mail.rockefeller.edu if you have pets!

Muffin (left) and Velvet (right).

Muffin (top) and Velvet (bottom). Photos by Sarah Mereby and Eddie Spencer.

Pooja Viswanathan: How old are you? In human years?

Velvet: We are 21 years old and 1.5 years old in human years.

 PV: Is there a story behind your names?

V: I was named by the people that work at the shelter that I am from. It is very fitting since my coat is very soft and sleek.

Muffin: I was named by my hoomans. They told me I am super cute and small like a muffin. I’m not so small anymore though.

PV: What is your first memory?

M: My first memory was waking up to find I had been put in a mailbox in the middle of winter. I was so scared! Thankfully I was rescued by the local shelter, which led to me meeting my hoomans. Meeting my hoomans is my favorite memory.

V: My first memory was meeting Muffin at the shelter. The shelter told me that I was the only survivor of all my siblings. Muffin has been my friend and a part of my family ever since.

PV: Which humans do you live with? When did you meet them?

V: We live with Sarah Mereby and Eddie Spencer. We met them at the shelter in January 2018.

PV: How do they belong in the Tri-I community?

M: Sarah is a Research Specialist at The Rockefeller University.

PV: Where do you live?

V: We live in Montclair, NJ. We just moved from Lyndhurst, NJ. We love our new house. We got to learn how to go up and down stairs and there are so many new places for us to hide. Also there are plenty of birds and squirrels to watch from the window.

PV: If you could live anywhere else in the world, where would you live?

V: I would live wherever my hoomans and Muffin would live.

M: I would live in a restaurant since I love to eat and would help eat any leftovers.

PV: What are your favorite foods?

M: I love to eat canned cat food. I do not have a favorite flavor. I eat so quickly that I can’t even remember what flavor I had or whether I had a full bowl to begin with. I also love to try to eat Velvet’s portion. Never know if Velvet had a better flavor or was given more food than me.

V: I love Friskies Shreds. My favorite flavor is salmon. I am very picky and have taught my hoomans to only give my shreds and not pate. Ew. I also like treats: Ahi Tuna flavor! I also like to drink water out of hooman’s glass. It always tastes best when it’s nice and cold. Sharing with hooman is the best. Although I don’t know why they get mad at me when I take a small lick of their water.

PV: What is your favorite weekend activity?

V: We like to hang out with our hoomans on the weekends. That’s the best. We normally like to watch TV with hoomans and sit in our cat tree while looking out the window. We also like to play with hooman. We love our feather toys.

M: I like to snuggle with Eddie.

V: I like to follow hoomans everywhere around the house to make sure to help them if they need my assistance.

PV: Besides your human roomie, who is your favorite human in the Tri-I community?

V: I have met Stephanie who works at Memorial Sloan Kettering. I love making new friends.

M: I can’t remember. I am a bit afraid of meeting new people.

PV: Do you have a funny story to share with us?

V: One time hoomans brought home a cat stuffed animal that is about the same size as us. We were so convinced it was real. It was very scary. We both approached it very slowly and pawed at it. We were worried we were being replaced by a new cat. Thankfully it’s just a decoration. It wishes it could be like us.

PV: Is there some way we can see more pictures of you on the interwebs?

V: You can follow us on the Instagram account @catasticday or use the hashtag #muffinandvelvet.

PV: If you could have any human ability, what would it be?

M: Being able to open cans of cat food. That’s the dream.

V: Being able to play the piano. I love when hoomans play piano. It’s very relaxing. I’ve attempted to play the piano myself by jumping on the piano keys but it doesn’t sound as good as when hooman plays.

 

Life on a Roll – Aurora over Snaefellsnes

Megan Elizabeth Kelley (Twitter @MeganEKelley)

Photos by Megan Elizabeth Kelley.

On the Northern coast of the Snaefellsnes peninsula in Iceland, there is a horse farm nestled between the water and the mountains where I stayed for a few nights. As is typical for winter in Iceland, the wind howled, rain alternated with snow, and clouds often obscured the stars, but for a few hours one night the skies opened up and unveiled the Aurora Borealis. At times, swirling light shimmered overhead like idle tracings, while at other times there seemed to be a green spotlight blazing across the sky. The wind and rain continued to blow in from the side—I realized that I was still in my pajamas and they were stacking up poorly against the elements, but the awe-inspiring sight of the aurora kept me outside for hours. I was grateful when the clouds eventually rolled in over the mountains, as I needed sleep and could not have otherwise torn myself away from such a sight.